Journal of Clinical Virology
Volume 43, Issue 4 , Pages 396-400, December 2008

The emergence of Nipah virus, a highly pathogenic paramyxovirus

  • Michael K. Lo

      Affiliations

    • Centers for Disease Control and Prevention, Measles, Mumps, Rubella, and Herpesviruses Laboratory Branch, 1600 Clifton Road, Mailstop C-22, Atlanta, GA 30333, United States
    • Emory University, Department of Microbiology and Immunology, 1510 Clifton Road, Atlanta, GA 30322, United States
    • ,
  • Paul A. Rota

      Affiliations

    • Centers for Disease Control and Prevention, Measles, Mumps, Rubella, and Herpesviruses Laboratory Branch, 1600 Clifton Road, Mailstop C-22, Atlanta, GA 30333, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 404 639 4181; fax: +1 404 639 4187.

Received 9 June 2008; accepted 14 August 2008. published online 06 October 2008.

Abstract 

Nipah virus first emerged in Malaysia and Singapore between 1998 and 1999, causing severe febrile encephalitis in humans with a mortality rate of close to 40%. In addition, a significant portion of those recovering from acute infection had relapse encephalitis and long-term neurological defects. Since its initial outbreak, there have been numerous outbreaks in Bangladesh and India, in which the mortality rate rose to approximately 70%. These subsequent outbreaks were distinct from the initial outbreak, both in their epidemiology and in their clinical presentations. Recent developments in diagnostics may expedite disease diagnosis and outbreak containment, while progress in understanding the molecular biology of Nipah virus could lead to novel therapeutics and vaccines for this deadly pathogen.

Keywords: Nipah virus, Encephalitis, Outbreak, Bangladesh, India

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1386-6532(08)00292-8

doi:10.1016/j.jcv.2008.08.007

Journal of Clinical Virology
Volume 43, Issue 4 , Pages 396-400, December 2008

Article Tools

* Image Usage & Resolution