Journal of Clinical Virology
Volume 29, Issue 3 , Pages 160-166 , March 2004

Occult hepatitis B virus infection does not affect liver histology or response to therapy with interferon alpha and ribavirin in intravenous drug users with chronic hepatitis C

  • Paolo Fabris

      Affiliations

    • Department of Infectious Diseases and Tropical Medicine, S. Bortolo Hospital, Viale Rodolfi, Vicenza 36100, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-0444-993-624; fax: +39-0444-993-616.
    • ,
  • Dave Brown

      Affiliations

    • Centre for Hepatology, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    • ,
  • Giulia Tositti

      Affiliations

    • Department of Infectious Diseases and Tropical Medicine, S. Bortolo Hospital, Viale Rodolfi, Vicenza 36100, Italy
    • ,
  • Loredana Bozzola

      Affiliations

    • Department of Pathology, S. Bortolo Hospital, Viale Rodolfi, Vicenza 36100, Italy
    • ,
  • Maria Teresa Giordani

      Affiliations

    • Department of Infectious Diseases and Tropical Medicine, S. Bortolo Hospital, Viale Rodolfi, Vicenza 36100, Italy
    • ,
  • Pierantonio Bevilacqua

      Affiliations

    • Department of Pathology, S. Bortolo Hospital, Viale Rodolfi, Vicenza 36100, Italy
    • ,
  • Fausto de Lalla

      Affiliations

    • Department of Infectious Diseases and Tropical Medicine, S. Bortolo Hospital, Viale Rodolfi, Vicenza 36100, Italy
    • ,
  • George J.M. Webster

      Affiliations

    • Centre for Hepatology, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    • ,
  • Geoffrey Dusheiko

      Affiliations

    • Centre for Hepatology, Royal Free and University College Medical School, Rowland Hill Street, London, UK

Received 30 December 2002 ,Revised 3 March 2003 ,Accepted 15 April 2003.

References 

  1. Blum HE, Galun E, Liang TJ, von Weizsacker F, Wands JR. Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J. Virol. 1991;65:1836–1842
  2. Blum HE, Liang TJ, Galun E, Wands JR. Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. Hepatology. 1991;14:56–63
  3. Brechot C, Degos F, Lugassy C, Thiers V, Zafrani S, Franco D, et al.  Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N. Engl. J. Med. 1985;312:270–276
  4. Cacciola I, Pollicino T, Squadrito G, Cerenzia G, Orlando ME, Raimondo G. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N. Engl. J. Med. 1999;341:22–26
  5. Carman WF, Van Deursen FJ, Mimms LT, Hardie D, Coppola R, Decker R, et al.  The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa, and Sardinia. Hepatology. 1997;26:1658–1666
  6. Chazouilleres O, Mamish D, Kim M, Carey K, Ferrell L, Roberts JP, et al  Occult’ hepatitis B virus as source of infection in liver transplant recipients. Lancet. 1994;343:142–146
  7. Chemin I, Jeantet D, Kay A, Trépo C. Role of silent hepatitis B virus in chronic hepatitis B surface antigen (–) liver disease. Antivir. Res. 2001;52:117–123
  8. De Maria N, Colantoni A, Friedlander L, Leandro G, Idilman R, Harig G, et al.  The impact of previous HBV infection in patients with chronic hepatitis C. Am. J. Gastroenterol. 2000;95:3529–3536
  9. Dickson RC, Everhart JE, Lake JR, Wei Y, Seaberg EC, Wiesner RH, et al.  Transmission of hepatitis B by transplantation of livers from donors positive for antibody to hepatitis B core antigen. The National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Gastroenterology. 1997;113:1668–1674
  10. EASL International Consensus Conference on Hepatitis C, Paris, 26–27 February, 1999. Consensus statement. J Hepatol 1999; 31 (Suppl 1): 3–8.
  11. Fong TL, Di Bisceglie AM, Gerber MA, Waggoner JG, Hoofnagle JH. Persistence of hepatitis B virus DNA in the liver after loss of HBsAg in chronic hepatitis B. Hepatology. 1993;18:1313–1318
  12. Fukuda R, Ishimura N, Niigaki M, Hamamoto S, Satoh S, Tanaka S, et al.  Serologically silent hepatitis B virus coinfection in patients with hepatitis C virus-associated chronic liver disease: clinical and virological significance. J. Med. Virol. 1999;58:201–207
  13. Fukuda R, Ishimura N, Hamamoto S, Moritani M, Uchida Y, Ishihara S, et al. Co-infection by serologically-silent hepatitis B virus may contribute to poor interferon response in patients with chronic hepatitis C by down-regulation of type-I interferon receptor gene expression in the liver. J Med Virol 2001;3:220–7.
  14. Gonzalez S, Navas S, Madejon A, Bartolome J, Castillo I, Moraleda G, et al.  Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C. J. Med. Virol. 1995;45:168–173
  15. Grob P, Jilg W, Bornhak H, Gerken G, Gerlich W, Gunther S, et al.  Serological pattern ‘anti-HBc alone’: report on a workshop. J. Med. Virol. 2000;62:450–455
  16. Grumayer ER, Panzer S, Ferenci P, Gadner H. Recurrence of hepatitis B in children with serologic evidence of past hepatitis B virus infection undergoing antileukemic chemotherapy. J. Hepatol. 1989;8:232–235
  17. Hoofnagle JH, Dusheiko GM, Schafer DF, Jones EA, Micetich KC, Young RC, et al.  Reactivation of chronic hepatitis B virus infection by cancer chemotherapy. Ann. Intern. Med. 1982;96:447–449
  18. Hu KQ. Occult hepatitis B virus infection and its clinical implications. J. Viral. Hepatol. 2002;9:243–247
  19. Imberti L, Cariani E, Bettinardi A, Zonaro A, Albertini A, Primi D. An immunoassay for specific amplified HCV sequences. J. Virol. Methods. 1991;34:233–243
  20. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al.  Histological grading and staging of chronic hepatitis. J. Hepatol. 1995;22:696–699
  21. Kazemi-Shirazi L, Petermann D, Muller C. Hepatitis B virus DNA in sera and liver tissue of HBsAg negative patients with chronic hepatitis C. J. Hepatol. 2000;33:785–790
  22. Koike K, Kobayashi M, Gondo M, Hayashi I, Osuga T, Takada S. Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients. J. Med. Virol. 1998;54:249–255
  23. Lai MY, Chen PJ, Yang PM, Sheu JC, Sung JL, Chen DS. Identification and characterization of intrahepatic hepatitis B virus DNA in HBsAg-seronegative patients with chronic liver disease and hepatocellular carcinoma in Taiwan. Hepatology. 1990;12:575–581
  24. Liaw YF, Chien RN, Lin SM, Yeh CT, Tsai SL, Sheen S, et al. Response of patients with dual hepatitis B virus and C virus infection to interferon therapy. J. Interferon Cytokine. Res. 1997;17:449–452
  25. Lok AS, Liang RH, Chiu EK, Wong KL, Chan TK, Todd D. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study. Gastroenterology. 1991;100:182–188
  26. Marcellin P, Giostra E, Martinot-Peignoux M, Loriot MA, Jaegle ML, Wolf P, et al.  Redevelopment of hepatitis B surface antigen after renal transplantation. Gastroenterology. 1991;100:1432–1434
  27. Marranconi F, Fabris P, Stecca C, Zampieri L, Bettini MC, Di Fabrizio N, et al.  Prevalence of anti-HCV and risk factors for hepatitis C virus infection in healthy pregnant women. Infection. 1994;22:333–337
  28. Minami M, Poussin K, Brechot C, Paterlini P. A novel PCR technique using Alu-specific primers to identify unknown flanking sequences from the human genome. Genomics. 1995;29:403–408
  29. Nirey K, Kaneko M, Moriyama M, Arakawa Y. The clinical features of chronic hepatitis C are not affected by coexistence of hepatitis B virus DNA in patients negative for hepatitis B surface antigen. Intervirology. 2000;43:95–101
  30. Sagnelli E, Coppola N, Scolastico C, Filippini P, Santantonio T, Stroffolini T, et al.  Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C, and delta viruses in patients with chronic hepatitis. Hepatology. 2000;32:1106–1110
  31. Sanchez-Quijano A, Jauregui JI, Leal M, Pineda JA, Castilla A, Abad MA, et al.  Hepatitis B virus occult infection in subjects with persistent isolated anti-HBc reactivity. J. Hepatol. 1993;17:288–293
  32. Sardo MA, Rodino G, Brancatelli S, Pernice M, Campo S, Squadrito G, et al.  Inapparent ‘wild-type’ and ‘e-minus variant’ HBV infection in patients with HCV-related chronic hepatitis. Liver. 1994;14:241–244
  33. Theilmann L, Arnold J, Tox U, Datsis K, Otto G, Hofmann W, et al.  Liver transplantation and de novo hepatitis B infection. Lancet. 1994;343:677–678
  34. Thiers V, Nakajima E, Kremsdorf D, Mack D, Schellekens H, Driss F, et al.  Transmission of hepatitis B from hepatitis-B-seronegative subjects. Lancet. 1988;2:1273–1276
  35. Torbernson M, Thomas DL. Occult hepatitis B. Lancet Infect. Dis. 2002;2:479–486
  36. Uchida T, Gotoh K, Shikata T. Complete nucleotide sequences and the characteristics of two hepatitis B virus mutants causing serologically negative acute or chronic hepatitis B. J. Med. Virol. 1995;45:247–252
  37. Uchida T, Kaneita Y, Gotoh K, Kanagawa H, Kouyama H, Kawanishi T, et al.  Hepatitis C virus is frequently coinfected with serum marker-negative hepatitis B virus: probable replication promotion of the former by the latter as demonstrated by in vitro cotransfection. J. Med. Virol. 1997;52:399–405
  38. Villa E, Grottola A, Buttafoco P, Trande P, Merighi A, Fratti N, et al.  Evidence for hepatitis B virus infection in patients with chronic hepatitis C with and without serological markers of hepatitis B. Dig. Dis. Sci. 1995;40:8–13
  39. Wachs ME, Amend WJ, Ascher NL, Bretan PN, Emond J, Lake JR, et al.  The risk of transmission of hepatitis B from HBsAg(−), HBcAb(+), HBIgM(−) organ donors. Transplantation. 1995;59:230–234
  40. Waite J, Gilson RJ, Weller IV, Lacey CJ, Hambling MH, Hawkins A, et al.  Hepatitis B virus reactivation or reinfection associated with HIV-1 infection. AIDS. 1988;2:443–448
  41. Wang JT, Wang TH, Sheu JC, Shih LN, Lin JT, Chen DS. Detection of hepatitis B virus DNA by polymerase chain reaction in plasma of volunteer blood donors negative for hepatitis B surface antigen. J. Infect. Dis. 1991;163:397–399
  42. Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, et al.  Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J. Virol. 1994;68:2671–2676
  43. Zignego AL, Foschi M, Laffi G, Monti M, Careccia G, Romanelli RG, et al.  Inapparent’ hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease. Hepatology. 1994;19:577–582
  44. Zignego AL, Fontana R, Puliti S, Barbagli S, Monti M, Careccia G, et al.  Impaired response to alpha interferon in patients with an inapparent hepatitis and hepatitis C virus coinfection. Arch. Virol. 1997;142:535–544

PII: S1386-6532(03)00117-3

doi: 10.1016/S1386-6532(03)00117-3

Journal of Clinical Virology
Volume 29, Issue 3 , Pages 160-166 , March 2004

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