High prevalence of human papillomavirus type 58 in Mexican colposcopy patients

Abstract 

Background: Cervical cancer is the second most common cancer of the women worldwide. Infection with some genotypes of human papillomavirus is the most important risk factor associated to cervical cancer. Objective: To determine the prevalence and genotypes of papillomavirus in biopsies of women with squamous intraepithelial lesion and cervical cancer. Study design: Two hundred sequential patients of colposcopy clinic were studied. HPV diagnosis was done by polymerase chain reaction using MY09/MY11 primers, for genotyping line blot hybridization was used. Results: A total of 186 women were β globin positive; 104 (55.9%) had histology diagnosis of low-grade squamous intraepitelial lesions (LSIL), 67 (36.0%) high-grade squamous intraepitelial lesions (HSIL) and 15 (8.1%) invasive cervical cancer (IC). The prevalence of HPV was 56.4% (104/185); HPV 58 was founded in 28.5% of all positive women, HPV 16 in 25.7%, HPV 18 in 13.3%, HPV 33 in 11.4% and 31 in 8.5%. In all grades of the lesions HPV 58 was the most frequently. Conclusions: The high prevalence of HPV 58 among Mexican women with HSIL and IC, has important implications in prophylaxis.

Keywords: Human papillomavirus, Cervical cancer, Mexico, Genotype 58

Abbreviations: HSIL, high-squamous intraepithelial lesions, IC, invasive cervical cancer, LSIL, low-grade squamous intraepithelial lesions