Journal of Clinical Virology
Volume 38, Issue 1 , Pages 64-69 , January 2007

Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland

  • Paula M. Kinnunen

      Affiliations

    • Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P.O. Box 66, 00014 University of Helsinki, Finland
    • Department of Virology, Haartman Institute, P.O. Box 21, 00014 University of Helsinki, Finland
    • Corresponding Author InformationCorresponding author at: Department of Virology, Haartman Institute, P.O. Box 21, 00014 University of Helsinki, Finland. Tel.: +358 9 191 26706/57049; fax: +358 9 191 26491.
  • ,
  • Christian Billich

      Affiliations

    • Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
  • ,
  • Christine Ek-Kommonen

      Affiliations

    • Finnish Food Safety Authority, Mustialankatu 3, 00790 Helsinki, Finland
    • Tel.: +358 50 514 3926.
  • ,
  • Heikki Henttonen

      Affiliations

    • Finnish Forest Research Institute, Vantaa Research Unit, P.O. Box 18, 01301 Vantaa, Finland
    • Tel.: +358 10 211 2430.
  • ,
  • Eva R.K. Kallio

      Affiliations

    • Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P.O. Box 66, 00014 University of Helsinki, Finland
    • Finnish Forest Research Institute, Vantaa Research Unit, P.O. Box 18, 01301 Vantaa, Finland
    • Department of Biological and Environmental Science, P.O. Box 35, University of Jyväskylä, FIN-40014, Finland
    • Tel.: +358 50 354 2232.
  • ,
  • Jukka Niemimaa

      Affiliations

    • Finnish Forest Research Institute, Vantaa Research Unit, P.O. Box 18, 01301 Vantaa, Finland
    • Tel.: +358 10 211 2682.
  • ,
  • Airi Palva

      Affiliations

    • Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P.O. Box 66, 00014 University of Helsinki, Finland
    • Tel.: +358 9 191 57058.
  • ,
  • Peter Staeheli

      Affiliations

    • Department of Virology, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    • Tel.: +49 761 203 6579.
  • ,
  • Antti Vaheri

      Affiliations

    • Department of Virology, Haartman Institute, P.O. Box 21, 00014 University of Helsinki, Finland
    • Helsinki University Central Hospital Laboratory (HUSLAB), P.O. Box 400, 00029 HUS, Finland
    • Tel.: +358 9 191 26490.
  • ,
  • Olli Vapalahti

      Affiliations

    • Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, P.O. Box 66, 00014 University of Helsinki, Finland
    • Department of Virology, Haartman Institute, P.O. Box 21, 00014 University of Helsinki, Finland
    • Helsinki University Central Hospital Laboratory (HUSLAB), P.O. Box 400, 00029 HUS, Finland
    • Tel.: +358 9 191 26604.

Received 1 December 2005 ,Revised 30 May 2006 ,Accepted 12 October 2006.

References 

  1. Berg A, Reid-Smith R, Larsson M, Bonnett B. Case control study of feline Borna disease in Sweden. Vet Rec. 1998;142:715–717
  2. Berg AL. Borna disease in cats. Vet Rec. 1999;145:87
  3. Berg AL, Dorries R, Berg M. Borna disease virus infection in racing horses with behavioral and movement disorders. Arch Virol. 1999;144:547–559
  4. Berg M, Johansson M, Montell H, Berg AL. Wild birds as a possible natural reservoir of Borna disease virus. Epidemiol Infect. 2001;127:173–178
  5. Billich C, Sauder C, Frank R, Herzog S, Bechter K, Takahashi K, et al. High-avidity human serum antibodies recognizing linear epitopes of Borna disease virus proteins. Biol Psychiatry. 2002;51:979–987
  6. Bode L, Reckwald P, Severus WE, Stoyloff R, Ferszt R, Dietrich DE, et al. Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies—the key marker triplet determining infection and prevailing in severe mood disorders. Mol Psychiatry. 2001;6:481–491
  7. Chalmers RM, Thomas DR, Salmon RL. Borna disease virus and the evidence for human pathogenicity: a systematic review. QJM. 2005;98:255–274
  8. de la Torre, JC, Carbone KM, Staeheli P, Stiz L, Richt JA, Ikuta K, Dietzschold B, Ludwig H, Bode L, Lipkin WI. International Committee on Taxonomy of Viruses: The Universal Virus Database. http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/index.htm. Last updated 28.6.2002. Accessed 27.9.2006.
  9. Durrwald R, Kolodziejek J, Muluneh A, Herzog S, Nowotny N. Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations. Microbes Infect. 2006;8:917–929
  10. Durrwald R, Ludwig H. Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. Zentralbl Veterinarmed B. 1997;44:147–184
  11. Flower R, Ludwig H. Presence of Borna disease virus (BDV)-specific structural components in human blood plasma. J Clin Virol. 2006;36:312–313author reply 314
  12. Grabner A, Fischer A. Symptomatology and diagnosis of Borna encephalitis of horses. A case analysis of the last 13 years. Tierarztl Prax. 1991;19:68–73
  13. Hagiwara K, Asakawa M, Liao L, Jiang W, Yan S, Chai J, et al. Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China. Vet Microbiol. 2001;80:383–389
  14. Hagiwara K, Kamitani W, Takamura S, Taniyama H, Nakaya T, Tanaka H, et al. Detection of Borna disease virus in a pregnant mare and her fetus. Vet Microbiol. 2000;72:207–216
  15. Hallensleben W, Schwemmle M, Hausmann J, Stitz L, Volk B, Pagenstecher A, et al. Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology. J Virol. 1998;72:4379–4386
  16. Hilbe M, Herrsche R, Kolodziejek J, Nowotny N, Zlinszky K, Ehrensperger F. Shrews as reservoir host of Borna disease virus. Emerg Infect Dis. 2006;12:675–677
  17. Hirano N, Kao M, Ludwig H. Persistent, tolerant or subacute infection in Borna disease virus-infected rats. J Gen Virol. 1983;64:1521–1530
  18. Ikuta K, Hagiwara K, Taniyama H, Nowotny N. Epidemiology and infection of natural animal hosts. In:  Carbone KM editors. Borna disease virus and its role in neurobehavioral disease. Washington DC, USA: ASM Press; 2002;p. 87–123
  19. Kamhieh S, Flower RL. Borna disease virus (BDV) infection in cats. A concise review based on current knowledge. Vet Q. 2006;28:66–73
  20. Kao M, Hamir AN, Rupprecht CE, Fu ZF, Shankar V, Koprowski H, et al. Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet Rec. 1993;132:241–244
  21. Kao M, Ludwig H, Gosztonyi G. Adaptation of Borna disease virus to the mouse. J Gen Virol. 1984;65:1845–1849
  22. Katz JB, Alstad D, Jenny AL, Carbone KM, Rubin SA, Waltrip RW . Clinical, serologic, and histopathologic characterization of experimental Borna disease in ponies. J Vet Diagn Invest. 1998;10:338–343
  23. Kolodziejek J, Durrwald R, Herzog S, Ehrensperger F, Lussy H, Nowotny N. Genetic clustering of Borna disease virus natural animal isolates, laboratory and vaccine strains strongly reflects their regional geographical origin. J Gen Virol. 2005;86:385–398
  24. Narayan O, Herzog S, Frese K, Scheefers H, Rott R. Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Science. 1983;220:1401–1403
  25. Okamoto M, Hagiwara K, Kamitani W, Sako T, Hirayama K, Kirisawa R, et al. Experimental vertical transmission of Borna disease virus in the mouse. Arch Virol. 2003;148:1557–1568
  26. Okamoto M, Kagawa Y, Kamitani W, Hagiwara K, Kirisawa R, Iwai H, et al. Borna disease in a dog in Japan. J Comp Pathol. 2002;126:312–317
  27. Planz O, Bechter KA, Schwemmle M. Human Borna disease infection. In:  Carbone KM editors. Borna disease virus and its role in neurobehavioral disease. Washington DC, USA: ASM Press; 2002;p. 179–225
  28. Pletnikov MV, Gonzalez-Dunia D, Stitz L. Experimental infection: pathogenesis of neurobehavioral disease. In:  Carbone KM editors. Borna disease virus and its role in neurobehavioral disease. Washington DC, USA: ASM Press; 2002;p. 125–178
  29. Rott R, Becht H. Natural and experimental Borna disease in animals. Curr Top Microbiol Immunol. 1995;190:17–30
  30. Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, et al. Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science. 1985;228:755–756
  31. Rubin SA, Waltrip RW, Bautista JR, Carbone KM. Borna disease virus in mice: host-specific differences in disease expression. J Virol. 1993;67:548–552
  32. Sauder C, Mizutani T, Yamaguchi K. Laboratory diagnosis. In:  Carbone KM editors. Borna disease virus and its role in neurobehavioral disease. Washington DC, USA: ASM Press; 2002;p. 45–85
  33. Sauder C, Staeheli P. Rat model of borna disease virus transmission: epidemiological implications. J Virol. 2003;77:12886–12890
  34. Staeheli P, Sauder C, Hausmann J, Ehrensperger F, Schwemmle M. Epidemiology of Borna disease virus. J Gen Virol. 2000;81:2123–2135
  35. Tsujimura K, Mizutani T, Kariwa H, Yoshimatsu K, Ogino M, Morii Y, et al. A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. J Vet Med Sci. 1999;61:113–117
  36. Vahlenkamp TW, Konrath A, Weber M, Muller H. Persistence of Borna disease virus in naturally infected sheep. J Virol. 2002;76:9735–9743
  37. von Sind JB. Der im Feld und auf der Reise geschwind heilende Pferdearzt, welcher einen gründlichen Unterricht von den gewöhnlichsten Krankheiten der Pferde im Feld und auf der Reise wie auch einen auserlesenen Vorrath der nützlichsten und durch die Erfahrung bewährtesten Heilungsmitteln eröffnet; 1767, 1781.
  38. Weissenbock H, Nowotny N, Caplazi P, Kolodziejek J, Ehrensperger F. Borna disease in a dog with lethal meningoencephalitis. J Clin Microbiol. 1998;36:2127–2130
  39. Wolff T, Heins G, Pauli G, Burger R, Kurth R. Failure to detect Borna disease virus antigen and RNA in human blood. J Clin Virol. 2006;36:309–311

PII: S1386-6532(06)00374-X

doi: 10.1016/j.jcv.2006.10.003

Journal of Clinical Virology
Volume 38, Issue 1 , Pages 64-69 , January 2007