Journal of Clinical Virology
Volume 45, Issue 3 , Pages 212-217 , July 2009

Prevalence of human cytomegalovirus co-infection in patients with chronic viral hepatitis B and C: A comparison of clinical and histological aspects

  • Aysen Bayram

      Affiliations

    • Department of Microbiology and Clinical Microbiology, School of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey
    • Corresponding Author InformationCorresponding author. Tel.: +90 342 3606060; fax: +90 342 3601617.
    • ,
  • Ayhan Özkur

      Affiliations

    • Department of Radiology, School of Medicine, University of Gaziantep, Turkey
    • ,
  • Suna Erkilic

      Affiliations

    • Department of Pathology, School of Medicine, University of Gaziantep, Turkey

Received 25 February 2009 ,Revised 2 May 2009 ,Accepted 6 May 2009.

References 

  1. Winn W, Allen S, Janda W, Koneman E, Procop G, Schreckenberger P, et al. Cytomegalovirus. In: Koneman's color atlas and textbook of diagnostic microbiology. 6th ed.. Philadelphia: Lippincott Williams &Wilkins; 2006;p. 1358–1359
  2. Sissons JG, Carmichael AJ. Clinical aspects and management of cytomegalovirus infection. J Infect. 2002;44:78–83
  3. Razonable RR, Rivero A, Brown RA, Hart GD, Espy MJ, van Cruijsen H, et al. Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection. Clin Transplant. 2003;17:114–120
  4. Griffiths P, Emery VC. Cytomegalovirus. Clinical virology. New York: Churchill Livingstone; 1997;p. 445–70
  5. Sinzger C, Bissinger AL, Viebahn R, Oettle H, Radke C, Schmidt CA, et al. Hepatocytes are permissive for human cytomegalovirus infection in human liver cell culture and in vivo. J Infect Dis. 1999;180:976–986
  6. Steininger C. Clinical relevance of cytomegalovirus infection in patients with disorders of the immune system. Clin Microbiol Infect. 2007;
  7. Ten Napel HH, Houthoff HJ, The TH. Cytomegalovirus hepatitis in normal and immune compromised hosts. Liver. 1984;4:184–194
  8. Bentata-Pessayre M, Beaugrand M, Callard P, Brun-Vesinet F, Krivitsky A, Mornet P, et al. Granulomatous hepatitis in cytomegalovirus infection in healthy adults. Ann Med Interne. 1987;138:353–357
  9. Mannstadt C, Stein G, Färber I. Clinical aspects of acute cytomegalovirus infection in adults without immune deficiency. Z Gesamte Inn Med. 1991;46:107–109
  10. Diego Lorenzo A, de González-Asanza C, Garcia Durán F, Piqueras B, Romero M, Salcedo M, et al. Cytomegalovirus infection as a cause of granulomatous hepatitis in immunocompetent patient. Rev Esp Enferm Dig. 1996;88:295–297
  11. Kunno A, Abe M, Yamada M, Murakami K. Clinical and histologic features of cytomegalovirus hepatitis in previously healthy adults. Liver. 1997;17:129–132
  12. de la Serna-Higuera C, González-Garcia M, Milicua JM, Muñoz V. Cytomegalovirus granulomatous hepatitis in an immunocompetent patient. Gastroenterol Hepatol. 1999;22:230–231
  13. Vujacich C, Vidiella G, Barcelona L, Sturba E, Stamboulian D. Cytomegalovirus infection with hepatic involvement in immunocompetent adults. Medicina (B Aires). 2006;66:206–210
  14. Rowshani AT, Bemelman FJ, van Leeuwen EMM, van Lier RAW, ten Berge IJM. Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation. 2005;79:381–386
  15. Rasmussen L, Morris S, Zipeto D, Fessel J, Wolitz R, Dowling A, et al. Quantitation of human cytomegalovirus DNA from peripheral blood cells of human immunodeficiency virus-infected patients could predict cytomegalovirus retinitis. J Infect Dis. 1995;171:177–182
  16. Paradowska E, Przepiorkiewicz M, Nowakowska D, Studzinska M, Wilczynski J, Emery VC, et al. Detection of cytomegalovirus in human placental cells by polymerase chain reaction. APMIS. 2006;114:764–771
  17. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1981;1:431–435
  18. Gandhi MK, Khanna R. Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis. 2004;4:725–738
  19. Prösch S, Wendt CEC, Reinke P, Priemer C, Oppert M, Krüger DH, et al. A novel link between stress and human cytomegalovirus (HCMV) infection sympathetic hyperactivity stimulates HCMV activation. Virology. 2000;272:357–365
  20. Gredmark S, Jonasson L, Van Gosliga D, Ernerudh J, Söderberg-Naucler C. Active cytomegalovirus replication in patients with coronary disease. Scand Cardiovasc J. 2007;41:230–234
  21. Daar ES, Lynn H, Donfield S, Gomperts E, O’Brien SJ, Hilgartner MW, et al. Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs. J Infect Dis. 2001;183:589–595
  22. Cavanaugh VJ, Guidotti LG, Chisari FV. Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice. J Virol. 1998;72:2630–2637
  23. Vandelli C, Zannini A, Piaggi V, Melegari M, Battilani R, Ventura E. What is the effect of a cytomegalovirus infection when superimposed on HBsAg-positive chronic hepatitis?. J Hepatol. 1987;4:343–348
  24. Marinelli RM, Dele Monache M, Gerardi R, Berardo C, Santolamazza M, Bruno G, et al. Liver pathology in cytomegalovirus infection associated with hepatitis B virus. J Int Med Res. 1993;21:154–157
  25. Zuschke CA, Herrera JL, Pettyjohn FS. Cytomegalovirus hepatitis mimicking an acute exacerbation of chronic hepatitis B. South Med J. 1996;89:1213–1216
  26. Shen L, Zhang L, Zhang X. An analysis of CMV infection in 115 cases with viral hepatitis. Zhonghua Yu Fang Yi Xue Za Zhi. 1996;30:157–159
  27. Lian Y, Wu W, Shi Y. Preliminary study on relationship between different viral pathogenesis and disease prognosis in patients with severe viral hepatitis. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1999;13:355–357
  28. Aldona K, Jacek W, Maciej Z, Wieslawa B, Joanna SZ. Cellular expression of human cytomegalovirus (HCMV) in children with chronic hepatitis B. Przegl Epidemiol. 2001;55:146–152
  29. Razonable RR, Burak KW, van Cruijsen H, Brown RA, Charlton MR, Smith TF, et al. The pathogenesis of hepatitis C virus is influenced by cytomegalovirus. Clin Infect Dis. 2002;35:974–981
  30. Singh N, Gayowski T, Wagener MM, Marino IR. Increased infections in liver transplant recipients with recurrent hepatitis C virus hepatitis. Transplantation. 1996;61:402–406
  31. Burak KW, Kremers WK, Batts KP, Wiesner RH, Rosen CB, Razonable RR, et al. Impact of cytomegalovirus infection, year of transplantation, and donor age on outcomes after liver transplantation for hepatitis C. Liver Transpl. 2002;8:362–369
  32. Rosen HR, Chou S, Corless CL, Gretch DR, Flora KD, Boudousquie A, et al. Cytomegalovirus viremia: risk factor for allograft cirrhosis after liver transplantation for hepatitis C. Transplantation. 1997;64:721–726
  33. Chopra KB, Demetris AJ, Blakolmer K, Dvorchik L, Laskus T, Wang LF, et al. Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantation. Transplantation. 2003;76:1487–1491
  34. Nebbia G, Mattes FM, Cholongitas E, Garcia-Diaz A, Samonakis DN, Burroughs AK, et al. Exploring the bidirectional interactions between human cytomegalovirus and hepatitis C virus replication after liver transplantation. Liver Transpl. 2007;13:130–135
  35. Teixeira R, Pastacaldi S, Davies S, Dhillon AP, Emery VC, Rolles K, et al. The influence of cytomegalovirus viraemia on the outcome of recurrent hepatitis C after liver transplantation. Transplantation. 2000;70:1454–1458
  36. Humar A, Kumar D, Rabound J, Caliendo AM, Moussa G, Levy G, et al. Interactions between cytomegalovirus, human herpesvirus-6, and the recurrence of hepatitis C after liver transplantation. Am J Transplant. 2002;2:461–466
  37. Numata S, Nakamura Y, Imamura Y, Honda J, Momosaki S, Kojiro M. Rapid quantitative analysis of human cytomegalovirus DNA by the real-time polymerase chain reaction method. Arch Pathol Lab Med. 2005;129:200–204
  38. Ghisetti V, Barbui A, Franchello A, Varetto S, Pittaluga F, Bobbio M, et al. Quantitation of cytomegalovirus DNA by the polymerase chain reaction as a predictor of disease in solid organ transplantation. J Med Virol. 2004;73:223–229
  39. Herrmann B, Larsson VC, Rubin CJ, Sund F, Eriksson BM, Arvidson J, et al. Comparison of a duplex quantitative real-time PCR assay and the COBAS Amplicor CMV Monitor test for detection of cytomegalovirus. J Clin Microbiol. 2004;42:1909–1914
  40. Yerly S, Perrin L, Van Delden C, Schaffer S, Thamm S, Wunderli W, et al. Cytomegalovirus quantification in plasma by an automated real-time PCR assay. J Clin Virol. 2007;38:298–303
  41. Jebbink J, Bai X, Rogers BB, Dawson DB, Scheuermann RH, Domiati-Saad R. Development of real-time PCR assays for the quantitative detection of Epstein-Barr virus and cytomegalovirus, comparison of TaqMan probes, and molecular beacons. J Mol Diagn. 2003;5:15–20
  42. Pumannova M, Roubalova K, Vitek A, Sajdova J. Comparison of quantitative competitive polymerase chain reaction-enzyme-linked immunosorbent assay with LightCycler-based polymerase chain reaction for measuring cytomegalovirus DNA in patients after hematopoietic stem cell transplantation. Diagn Microbiol Infect Dis. 2006;54:115–120
  43. Boeckh M, Huang M, Ferrenberg J, Stevens-Ayers T, Stensland L, Nichols WG, et al. Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR. J Clin Microbiol. 2004;42:1142–1148
  44. Allice T, Enrietto M, Pittaluga F, Varetto S, Franchello A, Marchiaro G, et al. Quantitation of cytomegalovirus DNA by real-time polymerase chain reaction in peripheral blood specimens of patients with solid organ transplants: comparison with end-point PCR and pp65 antigen test. J Med Virol. 2006;78:915–922
  45. Emery VC, Sabin CA, Cope AV, Gor D, Hassan-Walker AF, Griffiths PD. Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation. Lancet. 2000;335:2032–2036

PII: S1386-6532(09)00204-2

doi: 10.1016/j.jcv.2009.05.009

Journal of Clinical Virology
Volume 45, Issue 3 , Pages 212-217 , July 2009

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