Journal of Clinical Virology
Volume 46 , Pages S22-S26 , December 2009

Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system

Presented at the 2006 Pediatric Academic Societies/Society for Pediatric Research Annual Meeting, San Francisco, CA, April 29, 2006; Abstract # 752908

  • Sara E. Oliver

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham, United States
    • Currently affiliated with the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
    • ,
  • Gretchen A. Cloud

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, United States
    • ,
  • Pablo J. Sánchez

      Affiliations

    • Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States
    • ,
  • Gail J. Demmler

      Affiliations

    • Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States
    • ,
  • Wayne Dankner

      Affiliations

    • Department of Pediatrics, University of California at San Diego, United States
    • Currently affiliated with Parexel International, Durham, NC, United States.
    • ,
  • Mark Shelton

      Affiliations

    • Cook Children's Medical Center, Fort Worth, TX, United States
    • ,
  • Richard F. Jacobs

      Affiliations

    • Department of Pediatrics, University of Arkansas, Little Rock, United States
    • ,
  • Wendy Vaudry

      Affiliations

    • Department of Pediatrics, University of Alberta, Edmonton, Canada
    • ,
  • Robert F. Pass

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham, United States
    • ,
  • Seng-jaw Soong

      Affiliations

    • Department of Medicine, University of Alabama at Birmingham, United States
    • ,
  • Richard J. Whitley

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham, United States
    • ,
  • David W. Kimberlin

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham, United States
    • Corresponding Author InformationCorresponding author at: Division of Pediatric Infectious Diseases, The University of Alabama at Birmingham, 1600 Seventh Avenue South, CHB 303, Birmingham, AL 35233, United States. Tel.: +1 205 934-5316; fax: +1 205 975 9972.
    • ,
  • for the National Institute of Allergy, Infectious Diseases Collaborative Antiviral Study Group

Received 1 April 2009 ,Revised 3 August 2009 ,Accepted 13 August 2009.

References 

  1. Elek SD, Stern H. Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero. Lancet. 1974;1:1–5
  2. Arvin AM, Fast P, Myers M, Plotkin S, Rabinovich R. Vaccine development to prevent cytomegalovirus disease: report from the National Vaccine Advisory Committee. Clin Infect Dis. 2004;39:233–239
  3. Fowler KB, McCollister FP, Dahle AJ, Boppana S, Britt WJ, Pass RF. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr. 1997;130:624–630
  4. Harris S, Ahlfors K, Ivarsson S, Lernmark B, Svanberg L. Congenital cytomegalovirus infection and sensorineural hearing loss. Ear Hear. 1984;5:352–355
  5. Fowler KB, Dahle AJ, Boppana SB, Pass RF. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed?. J Pediatr. 1999;135:60–64
  6. Grosse SD, Ross DS, Dollard SC. Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment. J Clin Virol. 2008;41:57–62
  7. Demmler GJ. Infectious Diseases Society of America and Centers for Disease Control. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis. 1991;13:315–329
  8. Stagno S, Whitley RJ. Herpesvirus infections of pregnancy. Part I. Cytomegalovirus and Epstein-Barr virus infections. N Engl J Med. 1985;313:1270–1274
  9. McCracken GH, Shinefield HM, Cobb K, Rausen AR, Dische R, Eichenwald HF. Congenital cytomegalic inclusion disease A longitudinal study of 20 patients. Am J Dis Child. 1969;117:522–539
  10. Pass RF, Stagno S, Myers GJ, Alford CA. Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics. 1980;66:758–762
  11. Weller TH. The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. I. N Engl J Med. 1971;285:203–214
  12. Weller TH, Hanshaw JB. Virologic and clinical observations on cytomegalic inclusion disease. N Engl J Med. 1962;266:1233–1244
  13. Conboy TJ, Pass RF, Stagno S, Alford CA, Myers GJ, Britt WJ, et al. Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr. 1987;111:343–348
  14. Dollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol. 2007;
  15. Yow MD, Demmler GJ. Congenital cytomegalovirus disease—20 years is long enough. N Engl J Med. 1992;326:702–703
  16. Kimberlin DW, Lin CY, Sanchez PJ, Demmler GJ, Dankner W, Shelton M, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr. 2003;143:16–25
  17. Frankenburg WK, Dodds J, Archer P, Shapiro H, Bresnick B. The Denver II: a major revision and restandardization of the Denver Developmental Screening Test. Pediatrics. 1992;89:91–97
  18. Boppana SB, Fowler KB, Vaid Y, Hedlund G, Stagno S, Britt WJ, et al. Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics. 1997;99:409–414
  19. Noyola DE, Demmler GJ, Nelson CT, Griesser C, Williamson WD, Atkins JT, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 2001;138:325–331
  20. Chang LY, Huang LM, Gau SS, Wu YY, Hsia SH, Fan TY, et al. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007;356:1226–1234
  21. Hallioglu O, Topaloglu AK, Zenciroglu A, Duzovali O, Yilgor E, Saribas S. Denver developmental screening test II for early identification of the infants who will develop major neurological deficit as a sequalea of hypoxic-ischemic encephalopathy. Pediatr Int. 2001;43:400–404
  22. American Academy of Pediatrics. Cytomegalovirus infection. In:  Pickering LK,  Baker CJ,  Long SS,  Kimberlin DW editor. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed.. Elk Grove Village, IL: American Academy of Pediatrics; 2009;p. 275–280

☆ This work was supported under contract with the Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases (NIAID) (N01-AI-30025, N01-AI-65306, N01-AI-15113, N01-AI-62554), and by grants from the General Clinical Research Center Program (M01-RR00032) and the State of Alabama.

☆☆ Trial Registration. Clinicaltrials.gov identifier: NCT00001100.

PII: S1386-6532(09)00389-8

doi: 10.1016/j.jcv.2009.08.012

Journal of Clinical Virology
Volume 46 , Pages S22-S26 , December 2009

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