Journal of Clinical Virology
Volume 46, Issue 4 , Pages 354-359 , December 2009

Hepatitis B precore/core promoter mutations in isolates from HBV-monoinfected and HBV–HIV coinfected patients: A 3-yr prospective study

  • Lucila Cassino

      Affiliations

    • Centro Nacional de Referencia para el SIDA, Dto. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    • Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
  • ,
  • Natalia Laufer

      Affiliations

    • Centro Nacional de Referencia para el SIDA, Dto. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    • División de Enfermedades Infecciosas, Hospital Fernández, Buenos Aires, Argentina
  • ,
  • Horacio Salomon

      Affiliations

    • Centro Nacional de Referencia para el SIDA, Dto. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    • Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
  • ,
  • Rodolfo Campos

      Affiliations

    • Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
    • Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
  • ,
  • Jorge Quarleri

      Affiliations

    • Centro Nacional de Referencia para el SIDA, Dto. Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    • Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
    • Corresponding Author InformationCorresponding author at: Centro Nacional de Referencia para el SIDA, Paraguay 2155-Piso 11, 1121 Buenos Aires, Argentina. Tel.: +54 11 4508 3689; fax: +54 11 4508 3705.

Received 11 August 2009 ,Accepted 9 September 2009.

References 

  1. Sulkowski MS. Viral hepatitis and HIV coinfection. J Hepatol. 2008;48(2):353–367
  2. Colin JF, Cazals-Hatem D, Loriot MA, Martinot-Peignoux M, Pham BN, Auperin A, et al. Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men. Hepatology. 1999;29(4):1306–1310
  3. Sumi H, Yokosuka O, Seki N, Arai M, Imazeki F, Kurihara T, et al. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology. 2003;37:19–26
  4. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet. 1989;2(8663):588–591
  5. Lok AS, Akarca U, Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci USA. 1994;91:4077–4081
  6. Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol. 1994;68:8102–8110
  7. Quarleri J, Moretti F, Bouzas MB, Laufer N, Gómez Carrillo M, Giuliano SF, et al. Hepatitis B virus genotype distribution and its lamivudine-resistant mutants in HIV-coinfected patients with chronic and occult hepatitis B. AIDS Res Hum Retroviruses. 2007;23(4):525–531
  8. Chan HL, Hussain M, Lok AS. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology. 1999;29(3):976–984
  9. Torres-Puente M, Bracho MA, Jiménez N, García-Robles I, Moya A, González-Candelas F. Sampling and repeatability in the evaluation of hepatitis C virus genetic variability. J Gen Virol. 2003;84:2343–2350
  10. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 1997;25:4876–4882
  11. Kumar S, Tamura K, Nei M, MEGA3: . Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform. 2004;5:150–163
  12. Uitenbroek DG. “SISA-Binomial.” http://www.quantitativeskills.com/sisa/distributions/binomial.htm; 1997 [1.01.2004].
  13. Piñeiro y Leone FG, Pezzano SC, Torres C, Rodríguez CE, Eugenia Garay M, Fainboim HA, et al. Hepatitis B virus genetic diversity in Argentina: dissimilar genotype distribution in two different geographical regions; description of hepatitis B surface antigen variants. J Clin Virol. 2008;42(4):381–388
  14. Ramos B, Núñez M, Martín-Carbonero L, Sheldon J, Rios P, Labarga P, et al. Hepatitis B virus genotypes and lamivudine resistance mutations in HIV/hepatitis B virus-coinfected patients. J Acq Immune Def Synd. 2007;44(5):557–561
  15. Du H, Li T, Zhang HY, He ZP, Dong QM, Duan XZ, et al. Correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter/precore with clinical features of chronic HBV infection. Liver Int. 2007;27(2):240–246
  16. Cho SW, Hahm KB, Kim JH. Reversion from precore/core promoter mutants to wild-type hepatitis B virus during the course of lamivudine therapy. Hepatology. 2000;32(5):1163–1169
  17. Tacke F, Gehrke C, Luedde T, Heim A, Manns MP, Trautwein C. Basal core promoter and precore mutations in the hepatitis B virus genome enhance replication efficacy of Lamivudine-resistant mutants. J Virol. 2004;78(16):8524–8535
  18. Gómez-Gonzalo M, Carretero M, Rullas J, Lara-Pezzi E, Aramburu J, Berkhout B, et al. The hepatitis B virus X protein induces HIV-1 replication and transcription in synergy with T-cell activation signals: functional roles of NF-kappaB/NF-AT and SP1-binding sites in the HIV-1 long terminal repeat promoter. J Biol Chem. 2001;276(38):35435–35443
  19. Kramvis A, Kew MC. Structure and function of the encapsidation signal of hepadnaviridae. J Viral Hepat. 1998;5(6):357–367
  20. França PH, González JE, Munné MS, Brandão LH, Gouvea VS, Sablon E, et al. Strong association between genotype F and hepatitis B virus (HBV) e antigen-negative variants among HBV-infected Argentinean blood donors. J Clin Microbiol. 2004;42(11):5015–5021

 Sources of support: This work was partly supported by grants from Universidad de Buenos Aires (UBA; M431), and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP6116).

PII: S1386-6532(09)00431-4

doi: 10.1016/j.jcv.2009.09.015

Journal of Clinical Virology
Volume 46, Issue 4 , Pages 354-359 , December 2009