Journal of Clinical Virology
Volume 46, Issue 4 , Pages 318-324 , December 2009

Incidence, molecular epidemiology and clinical presentations of human metapneumovirus; assessment of its importance as a diagnostic screening target

  • Eleanor Gaunt

      Affiliations

    • Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 131 650 7945; fax: +44 131 650 6511.
    • ,
  • E. Carol McWilliam-Leitch

      Affiliations

    • Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    • ,
  • Kate Templeton

      Affiliations

    • Department of Virology, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, United Kingdom
    • ,
  • Peter Simmonds

      Affiliations

    • Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom

Received 22 May 2009 ,Revised 8 September 2009 ,Accepted 11 September 2009.

References 

  1. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RAM, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719–724
  2. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350:443–450
  3. Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory tract infections in all age groups. J Infect Dis. 2002;186:1330–1334
  4. Heikkinen T, Järvinen A. The common cold. The Lancet. 2003;361:51–59
  5. Bastien N, Ward D, Van Caeseele P, Brandt K, Lee SHS, McNabb G, et al. Human metapneumovirus infection in the Canadian population. J Clin Microbiol. 2003;41:4642–4646
  6. Esper F, Martinello RAA, Boucher D, Weibel C, Ferguson D, Landry MAL, et al. A 1 year experience with human metapneumovirus in children aged <5 years. J Infect Dis. 2004;189:1388–1396
  7. Esper F, Boucher D, Weibel C, Martinello RA, Kahn JS. Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging respiratory infection in children. Pediatrics. 2003;111:1407–1410
  8. Falsey AR, Erdman D, Anderson LJ, Walsh EE. Human metapneumovirus infections in young and elderly adults. J Infect Dis. 2003;187:785–790
  9. Galiano M, Videla C, Sánchez Puch S, Martinez A, Echavarría M, Carballal G. Evidence of human metapneumovirus in children in Argentina. J Med Virol. 2004;72:299–303
  10. Gerna G, Campanini G, Rovida F, Sarasini A, Lilleri D, Paolucci S, et al. Changing circulation rate of human metapneumovirus strains and types among hospitalized pediatric patients during three consecutive winter–spring seasons. Arch Virol. 2005;150:2365–2375
  11. Ijpma FFABD, Cotton MF, Pieper CH, Kimpen JLL, van den Hoogen BG, van Doornum GJJ, et al. Human metapneumovirus infection in hospital referred South African children. J Med Virol. 2004;73:486–493
  12. McAdam AJ, Hasenbein ME, Feldman HA, Cole SE, Offermann JT, Riley AM, et al. Human metapneumovirus in children tested at a tertiary care hospital. J Infect Dis. 2004;190:20–26
  13. Peiris JSTW, Chan KH, Khong PL, Guan Y, Lau YL, Chiu SS. Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis. 2003;9:628–633
  14. van den Hoogen BG, van Doornum GJJ, Fockens JC, Cornelissen JJ, Beyer WEP, de Groot R, et al. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis. 2003;188:1571–1577
  15. von Linstow ML, Larsen HH, Eugen-Olsen J, Koch A, Winther TN, Meyer AM, et al. Human metapneumovirus and respiratory syncytial virus in hospitalized Danish children with acute respiratory tract infection. Scand J Infect Dis. 2004;36:578–584
  16. Stockton JSI, Fleming D, Zambon M. Human metapneumovirus as a cause of community-acquired respiratory illness. Emerg Infect Dis. 2002;8:897–901
  17. Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-associated hospitalizations among US children 1980–1996. JAMA. 1999;282:1440–1446
  18. Boivin G, De Serres G, Côté S, Gilca R, Abed Y, Rochette L, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis. 2003;9:634–640
  19. Agapov E, Sumino KAC, Gaudreaultâ-Keener M, Storch GAA, Holtzman MAJ. Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness. J Infect Dis. 2006;193:396–403
  20. Matsuzaki Y, Itagaki T, Abiko C, Aoki Y, Suto A, Mizuta K. Clinical impact of human metapneumovirus genotypes and genotype-specific seroprevalence in Yamagata, Japan. J Med Virol. 2008;80:1084–1089
  21. Vicente D, Montes M, Cilla G, Perez-Yarza EG, Perez-Trallero E. Differences in clinical severity between genotype A and genotype B human metapneumovirus infection in children. Clin Infect Dis. 2006;42:e111–e113
  22. Mackay IM, Bialasiewicz S, Jacob KC, McQueen E, Arden KE, Nissen MD, et al. Genetic diversity of human metapneumovirus over 4 consecutive years in Australia. J Infect Dis. 2006;193:1630–1633
  23. Cane PA, Matthews DA, Pringle CR. Analysis of respiratory syncytial virus strain variation in successive epidemics in one city. J Clin Microbiol. 1994;32:1–4
  24. Cane PA, Pringle CR. Evolution of subgroup A respiratory syncytial virus: evidence for progressive accumulation of amino acid changes in the attachment protein. J Virol. 1995;69:2918–2925
  25. Smyth RL, Mobbs KJ, O’Hea U, Ashby D, Hart CA. Respiratory syncytial virus bronchiolitis: disease severity, interleukin-8, and virus genotype. Pediatric Pulmonol. 2002;33:339–346
  26. Fletcher JN, Smyth RL, Thomas HM, Ashby D, Hart CA. Respiratory syncytial virus genotypes and disease severity among children in hospital. Arch Dis Child. 1997;77:508–511
  27. Hall CB, Walsh EE, Schnabel KC, Long CE, McConnochie KM, Hildreth SW, et al. Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J Infect Dis. 1990;162:1283–1290
  28. Martinello RAA, Chen MAD, Weibel C, Kahn JAS. Correlation between respiratory syncytial virus genotype and severity of illness. J Infect Dis. 2002;186:839–842
  29. Venter M, Madhi SA, Tiemessen CT, Schoub BD. Genetic diversity and molecular epidemiology of respiratory syncytial virus over four consecutive seasons in South Africa: identification of new subgroup A and B genotypes. J Gen Virol. 2001;82:2117–2124
  30. White LJ, Waris M, Cane PA, Nokes DJ, Medley GF. The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection. Epidemiol Infect. 2005;133(2):279–289133
  31. Venter M, Collinson M, Schoub BD. Molecular epidemiological analysis of community circulating respiratory syncytial virus in rural South Africa: comparison of viruses and genotypes responsible for different disease manifestations. J Med Virol. 2002;68:452–461
  32. Templeton KE, Scheltinga SA, Beersma MFC, Kroes ACM, Claas ECJ. Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by Influenza A and Influenza B viruses, respiratory syncytial virus and parainfluenza viruses 1,2, 3 and 4. J Clin Microbiol. 2004;42:1564–1569
  33. Albert H, Carmen E, Gabi H, Patricia PA. Rapid and quantitative detection of human adenovirus DNA by real-time PCR. J Med Virol. 2003;70:228–239
  34. Chano F, Rousseau C, Laferriere C, Couillard M, Charest H. Epidemiological survey of human metapneumovirus infection in a large pediatric tertiary care center. J Clin Microbiol. 2005;43:5520–5525
  35. Manning A, Russell V, Eastick K, Leadbetter GAH, Hallam N, Templeton K, et al. Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses. J Infect Dis. 2006;194:1283–1290
  36. Kumar S, Tamura K, Nei M. MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers. Comput Appl Biosci. 1994;10:189–191
  37. Boivin G, Serres GD, Hamelin ME, Cote S, Argouin M, Tremblay G, et al. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long term care facility. Clin Infect Dis. 2007;44:1152–1158
  38. Ulloa-Gutierrez R, Skippen P, Synnes A, Seear M, Bastien N, Li Y, et al. Life-threatening human metapneumovirus pneumonia requiring extracorporeal membrane oxygenation in a preterm infant. Pediatrics. 2004;114:e517–519
  39. Cuevas LE, Nasser AM, Dove W, Gurgel RQ, Greensill J, Hart CA. Human metapneumovirus and respiratory syncytial virus, Brazil. Emerg Infect Dis. 2003;9:1626–1628
  40. Tsai HP, Kuo PH, Liu CC, Wang JR. Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999. J Clin Microbiol. 2001;39:111–118
  41. Iwane MK, Edwards KM, Szilagyi PG, Walker FJ, Griffin MR, Weinberg GA, et al. Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics. 2004;113:1758–1764
  42. Straliotto SM, Siqueira MM, Muller RL, Fischer GB, Cunha MLT, Nestor SM. Viral etiology of acute respiratory infections among children in Porto Alegre, RS Brazil. Revista da Sociedade Brasileira de Medicina Tropical. 2002;35:283–291
  43. Monto AS, Bryan ER, Rhodes LM. The Tecumseh study of respiratory illness: VII. Further observations on the occurrence of respiratory syncytial virus and mycoplasma pneumoniae infections. Am J Epidemiol. 1974;100:458–468
  44. Williams JV, Wang CK, Yang CF, Tollefson SJ, House FS, Heck JM, et al. The role of human metapneumovirus in upper respiratory tract infections in children: a 20 year experience. J Infect Dis. 2006;193:387–395
  45. Duppenthaler A, Gorgievski-Hrisoho M, Frey U, Aebi C. Two-year periodicity of respiratory syncytial virus epidemics in Switzerland. Infection. 2003;31:75–80
  46. Mufson MA, Belshe RB, Orvell C, Norrby E. Respiratory syncytial virus epidemics: variable dominance of subgroups A and B strains among children 1981–1986. J Infect Dis. 1988;157:143–148
  47. Kim HW, Arrobio JO, Brandt CD, Jeffries BC, Pyles G, Reid JL, et al. Epidemiology of respiratory syncytial virus infection in Washington DC: I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am J Epidemiol. 1973;98:216–225
  48. Rafiefard F, Yun Z, Örvell C. Epidemiologic characteristics and seasonal distribution of human metapneumovirus infections in five epidemic seasons in Stockholm, Sweden, 2002–2006. J Med Virol. 2008;80:1631–1638
  49. Boivin GMI, Sloots TP, Madhi S, Freymuth F, Wolf D, Shemer-Avni Y, et al. Global genetic diversity of human metapneumovirus fusion gene. Emerg Infect Dis. 2004;10:1154–1157
  50. Peret TC, Hall CB, Schnabel KC, Golub JA, Anderson LJ. Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community. J Gen Virol. 1998;79:2221–2229
  51. Endo R, Ebihara T, Ishiguro N, et al. Detection of four genetic subgroup-specific antibodies to human metapneumovirus attachment (G) protein in human serum. J Gen Virol. 2008;89:1970–1977
  52. Skiadopoulos MH, Biacchesi S, Buchholz UJ, Riggs JM, Surman SR, Amaro-Carambot E, et al. The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness. J Virol. 2004;78:6927–6937
  53. MacPhail M, Schickli JH, Tang RS, Kaur J, Robinson C, Fouchier RAM, et al. Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design. J Gen Virol. 2004;85:1655–1663

PII: S1386-6532(09)00432-6

doi: 10.1016/j.jcv.2009.09.016

Journal of Clinical Virology
Volume 46, Issue 4 , Pages 318-324 , December 2009

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