Journal of Clinical Virology
Volume 46 , Pages S16-S21 , December 2009

Histological findings in foetuses congenitally infected by cytomegalovirus

  • Liliana Gabrielli

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy
    • Corresponding Author InformationCorresponding author at: Operative Unit of Microbiology, St. Orsola-Malpighi GH, Via Massarenti 9, 40138 Bologna, Italy. Tel.: +39 051 6364645; fax: +39 051 307397.
    • ,
  • Maria Paola Bonasoni

      Affiliations

    • Operative Unit of Pathology, St. Maria Nuova Hospital, Reggio-Emilia, Italy
    • ,
  • Tiziana Lazzarotto

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Stefania Lega

      Affiliations

    • Operative Unit of Pathology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Donatella Santini

      Affiliations

    • Operative Unit of Pathology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Maria Pia Foschini

      Affiliations

    • Department of Hematology, Oncology and Laboratory Medicine, Bellaria Hospital, Bologna, Italy
    • ,
  • Brunella Guerra

      Affiliations

    • Department of Obstetrics and Gynecology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Federica Baccolini

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Giulia Piccirilli

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Angela Chiereghin

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Evangelia Petrisli

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Giorgio Gardini

      Affiliations

    • Operative Unit of Pathology, St. Maria Nuova Hospital, Reggio-Emilia, Italy
    • ,
  • Marcello Lanari

      Affiliations

    • Operative Unit of Preventive Paediatrics and Neonatology, St. Orsola Malpighi GH, University of Bologna, Italy
    • ,
  • Maria Paola Landini

      Affiliations

    • Operative Unit of Microbiology, St. Orsola Malpighi GH, University of Bologna, Italy

Received 1 April 2009 ,Revised 17 September 2009 ,Accepted 21 September 2009.

References 

  1. Peckham CS. Cytomegalovirus infection: congenital and neonatal disease. Scand J Infect Suppl. 1991;78:82–87
  2. Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17:253–276
  3. Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med. 1992;326:663–667
  4. Guerra B, Simonazzi G, Puccetti C, Lanari M, Farina A, Lazzarotto T, et al. Ultrasound prediction of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol. 2008;198(380):e1–e7
  5. Guerra B, Lazzarotto T, Quarta S, Lanari M, Bovicelli L, Nicolosi A, et al. Prenatal diagnosis of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol. 2000;183:476–482
  6. Gouarin S, Gault E, Vabret A, Cointe D, Rozenberg F, Grangeot-Keros L, et al. Real-time PCR quantification of human cytomegalovirus DNA in amniotic fluid samples from mothers with primary infection. J Clin Microbiol. 2002;40:1767–1772
  7. Lazzarotto T, Guerra B, Lanari M, Gabrielli L, Landini MP. New advances in the diagnosis of congenital cytomegalovirus infection. J Clin Virol. 2008;41:192–197
  8. Gleaves CA, Smith TF, Shuster EA, Pearson GR. Rapid detection of cytomegalovirus in MRC-5 cells inoculated with urine specimens by using low-speed centrifugation and monoclonal antibody to an early antigen. J Clin Microbiol. 1984;19:917–919
  9. Lazzarotto T, Gabrielli L, Foschini MP, Lanari M, Guerra B, Eusebi V, et al. Congenital cytomegalovirus infection in twin pregnancies: viral load in the amniotic fluid and pregnancy outcome. Pediatrics. 2003;112:e153–e157
  10. Ludwig A, Hengel H. Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. Euro Surveill. 2009;14:26–32
  11. Kuban JD, Allred EN, Leviton A. Thymus involution and cerebral white matter damage in extremely low gestational age neonates. Biol Neonate. 2006;90:252–257
  12. Smith C, Squier MV. Acquired diseases of the Nervous System. In:  Keeling JW editors. Fetal and neonatal pathology. 4th edition. London: Springer-Verlag; 2007;p. 727–734
  13. Ross SA, Boppana SB. Congenital cytomegalovirus infection: outcome and diagnosis. Semin Pediatr Infect Dis. 2005;16:44–49
  14. Dollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol. 2007;17:355–363
  15. Pass RF. Cytomegalovirus infection. Pediatr Rev. 2002;23:163–169
  16. Leung AK, Sauve RS, Davies HD. Congenital cytomegalovirus infection. J Natl Med Assoc. 2003;95:213–218
  17. Kylat RI, Kelly EN, Ford-Jones EL. Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infection. Eur I Pediatr. 2006;165:773–778

PII: S1386-6532(09)00474-0

doi: 10.1016/j.jcv.2009.09.026

Journal of Clinical Virology
Volume 46 , Pages S16-S21 , December 2009

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