Journal of Clinical Virology
Volume 47, Issue 1 , Pages 97-99 , January 2010

Resolution of chronic hepatitis Delta after 1 year of combined therapy with pegylated interferon, tenofovir and emtricitabine

  • Wael Mansour

      Affiliations

    • Laboratoire HIFIH UPRES EA 3859, Faculté de Médecine d’Angers, France
    • Laboratoire de virologie, CHU Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • ,
  • Alexandra Ducancelle

      Affiliations

    • Laboratoire HIFIH UPRES EA 3859, Faculté de Médecine d’Angers, France
    • Laboratoire de virologie, CHU Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • ,
  • Frédéric Le Gal

      Affiliations

    • Laboratoire de virologie, CH&U Avicenne, associé au CNR des hépatites B, C et Delta, 125, boulevard de Stalingrad 93009 Bobigny cedex, France
    • ,
  • Hélène Le Guillou-Guillemette

      Affiliations

    • Laboratoire HIFIH UPRES EA 3859, Faculté de Médecine d’Angers, France
    • Laboratoire de virologie, CHU Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • ,
  • Pierre Abgueguen

      Affiliations

    • Service des Maladies Infectieuses et Tropicales, CHU, Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • ,
  • Adeline Pivert

      Affiliations

    • Laboratoire HIFIH UPRES EA 3859, Faculté de Médecine d’Angers, France
    • Laboratoire de virologie, CHU Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • ,
  • Paul Calès

      Affiliations

    • Laboratoire HIFIH UPRES EA 3859, Faculté de Médecine d’Angers, France
    • Service d’Hépato-Gastroentérologie, CHU, Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • ,
  • Emmanuel Gordien

      Affiliations

    • Laboratoire de virologie, CH&U Avicenne, associé au CNR des hépatites B, C et Delta, 125, boulevard de Stalingrad 93009 Bobigny cedex, France
    • ,
  • Françoise Lunel

      Affiliations

    • Laboratoire HIFIH UPRES EA 3859, Faculté de Médecine d’Angers, France
    • Laboratoire de virologie, CHU Angers, 4, rue Larrey 49933, Angers cedex 9, France
    • Corresponding Author InformationCorresponding author at: Laboratory of Virology, Hospital of Angers, 4 rue Larrey, 49933 Angers Cedex 9, France. Tel.: +33 2 41 35 54 93; fax: +33 2 41 35 41 64.

Received 3 June 2009 ,Revised 22 September 2009 ,Accepted 24 September 2009.

References 

  1. Rizzetto M, Canese MG, Aricò S, Crivelli O, Trepo C, Bonino F, et al. Immunofluorescence detection of a new antigen-antibody system delta/anti-delta associated to the hepatitis B virus in the liver and the serum of HBs-Ag carriers. Gut. 1977;18:997–1003
  2. Hsieh TH, Liu CJ, Chen DS, Chen PJ. Natural course and treatment of hepatitis D virus infection. J Formos Med Assoc. 2006;105:869–881
  3. Farci P. Delta hepatitis: an update. J Hepatol. 2003;39:S212–S219
  4. Castelnau C, Le Gal F, Ripault MP, Gordien E, Martinot-Peignoux M, Boyer N, et al. Efficacy of peginterferon alpha-2b in chronic hepatitis delta: relevance of quantitative RT-PCR for follow-up. Hepatology. 2006;44:728–735
  5. Le Gal F, Gordien E, Affolabi D, Hanslik T, Alloui C, Dény P, et al. Quantification of hepatitis delta virus RNA in serum by consensus real-time PCR indicates different patterns of virological response to interferon therapy in chronically infected patients. J Clin Microbiol. 2005;43:2363–2369
  6. Radjef N, Gordien E, Ivaniushina V, Gault E, Anaïs P, Drugan T, et al. Molecular phylogenetic analyses indicate a wide and ancient radiation of African hepatitis delta virus, suggesting a Deltavirus genus of at least seven major clades. J Virol. 2004;78:2537–2544
  7. Williams V, Brichler S, Radjef N, Lebon P, Goffard A, Hober D, et al. Hepatitis delta virus proteins repress hepatitis B virus enhancers and activate the alpha/beta interferon-inducible MxA gene. J Gen Virol. 2009;90:2759–2767
  8. Bozdayi A, Aslan N, Bozdayi G, Türkyilmaz AR, Sengezer T, Wend U, et al. Molecular epidemiology of hepatitis B, C and D viruses in Turkish patients. Arch Virol. 2004;149:2115–2129
  9. Farci P, Roskams T, Chessa L, Peddis G, Mazzoleni AP, Scioscia R, et al. Long-term benefit of interferon alpha therapy of chronic hepatitis D: regression of advanced hepatic fibrosis. Gastroenterology. 2004;126:1740–1749
  10. Gozlan J, Lacombe K, Gault E, Raguin G, Girard PM. Complete cure of HBV-HDV co-infection after 24 weeks of combination therapy with pegylated interferon and ribavirin in a patient co-infected with HBV/HCV/HDV/HIV. J Hepatol. 2009;50:432–434
  11. Van Bömmel F, Wünsche T, Mauss S, Reinke P, Bergk A, Schürmann D, et al. Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection. Hepatology. 2004;40:1421–1425
  12. Wursthorn K, Lutgehetmann M, Dandri M, Volz T, Buggisch P, Zollner B, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology. 2006;44:675–684

PII: S1386-6532(09)00475-2

doi: 10.1016/j.jcv.2009.09.027

Journal of Clinical Virology
Volume 47, Issue 1 , Pages 97-99 , January 2010

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