Journal of Clinical Virology
Volume 46 , Pages S1-S5 , December 2009

Congenital cytomegalovirus: Public health action towards awareness, prevention, and treatment

Received 4 September 2009 ,Revised 7 October 2009 ,Accepted 7 October 2009.

References 

  1. Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17(4):253–276
  2. Seale H, Booy R, MacIntyre C. Trends in hospitalisations for diagnosed congenital cytomegalovirus in infants and children in Australia. BMC Pediatr. 2009;9:7
  3. Pereira L, Maidji E. Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on tropholasts converge. Curr Top Microbiol Immunol. 2008;325:383–395
  4. Istas A, Demmler G, Dobbins J, Stewart J. Surveillance for congenital cytomegalovirus disease: a report from the National Congenital Cytomegalovirus Disease Registry. Clin Infect Dis. 1995;20(3):665–670
  5. Noyola D, Demmler G, Nelson C, Griesser C, Atkins J, Rozelle J, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr. 2001;138:325–331
  6. Cheeran M, Lokensgard J, Schleiss M. Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev. 2009;22(1):99–126
  7. Coats D, Demmler G, Paysse E, Du, Libby, the Congenital CMV Longitudinal Study Group. Ophthalmologic findings in children with congenital cytomegalovirus infection. J AAPOS;2000;4:110–6.
  8. Pass R. Congenital cytomegalovirus infection and hearing loss. Herpes. 2005;12(2):50–55
  9. Foulon I, Naessens A, Foulon W, Casteels A, Gordts F. A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. J Pediatr. 2008;153(1):84–88
  10. Williamson W, Demmler G, Percy A, Catlin F. Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. Pediatrics. 1992;90(6):8620866
  11. Grosse S, Ross D, Dollard S. Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: a quantitative assessment. J Clin Virol. 2008;41(2):57–62
  12. Yow M, Williamson D, Leeds L, Thompson P, Woodward R, Walmus B, et al. Epidemiologic characteristics of cytomegalovirus infection in mothers and their infants. Am J Obstet Gynecol. 1988;158:1189–1195
  13. Staras S, Dollard S, Radford K, Flanders W, Pass R, Cannon M. Seroprevalence of cytomegalovirus infection in the Untied States, 1988–1994. Clin Infect Dis. 2006;43:1143–1151
  14. Demmler G. Cytomegalovirus infection: Back to the future or no more elephants?. Clin Infect Dis. 2006;43(9):1152–1153
  15. Fowler K, Stagno S, Pass R, Britt W, Boll T, Alford C. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med. 1992;326(10):663–667
  16. Yow M, Demmler G. Congenital CMV disease: 20 years is long enough. N Engl J Med. 1992;326:702–703
  17. Fowler K, Stagno S, Pass R. Maternal age and congenital cytomegalovirus infection: screening of two diverse newborn populations, 1980–1990. J Infect Dis. 1993;168(3):552–556
  18. Stagno S, Dworsky M, Torres J, Mesa T, Hirsh T. Prevalence and importance of congenital cytomegalovirus infection in three different populations. J Pediatr. 1982;101(6):897–900
  19. Colugnati F, Staras S, Dollard S, Cannon M. Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis. 2007;7:71
  20. Hassan J, Connell J. Translational min-review series on infectious disease: congenital cytomegalovirus infection: 50 years on. Clin Exp Immunol. 2007;149(2):205–210
  21. Kimberlin D, Lin C-Y, Sanchez P, Demmler G, Dankner W, Shelton M, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatrics. 2003;143:17–26
  22. Kimberlin D, Acosta E, Sanchez P, Sood S, Agarwal V, Homans J, et al. Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. J Infect Dis. 2008;197(6):836–845
  23. Arn P. Newborn screening: current status. Health Aff (Millwood). 2007;26(2):559–566
  24. Joint Committee on Infant Hearing, American Academy of Audiology, American Academy of Pediatrics, American Speech-Language Association, Directors of Speech, Hearing Programs in State Health, Welfare Agencies . Year 2000 position statement: principles and guidelines for early hearing detection and intervention programs. Pediatrics. 2000;106(4):798–817
  25. Dollard S, Grosse S, Ross D. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol. 2007;17(5):35–363
  26. Fowler K, Dahle A, Boppana S, Pass R. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed?. J Pediatr. 1999;135(1):60–64
  27. Barbi M, Binda S, Caroppo S, Primache V. Neonatal screening for congenital cytomegalovirus infection and hearing loss. J Clin Virol. 2006;35(2):206–209
  28. Walter S, Atkinson C, Sharland M, Rice P, Raglan E, Emery V, et al. Congenital cytomegalovirus: association between dried blood spot viral load and hearing loss. Arch Dis Child Fetal Neonatal Ed. 2008;93(4):F280–F285
  29. Demmler G, Buffone G, Schimbor C, May R. Detection of cytomegalovirus in urine from newborns by polymerase chain reaction DNA amplification. J Infect Dis. 1988;158:1177–1184
  30. Balcarek K, Warren W, Smith R, Lyon M, Pass R. Neonatal screening for congenital cytomegalovirus infection by detection of virus in saliva. J Infect Dis. 1993;167(6):1433–1436
  31. van der Sande M, Kave S, Miles D, Waight P, Jeffries D, Ojuila O, et al. Risk factors for and clinical outcome of congenital cytomegalovirus infection in peri-urban West African birth cohort. PLoS One. 2007;2(6):e492
  32. Guibert G, Warszawski J, Le Chenandec J, Blanche S, Benmebarek Y, Mandelbrot L, et al. Decreased risk of congenital cytomegalovirus infection in children born to HIV-infected mothers in an era of highly active anti-retroviral therapy. Clin Infect Dis. 2009;48(11):1516–1525
  33. Lazzarotto T, Guerra B, Lanari M, Gabrielli L, Landini M. New advances in the diagnosis of congenital cytomegalovirus infection. J Clin Virol. 2008;41(3):192–197
  34. Griffiths P. Strategies to prevent CMV infection in the neonate. Semin Neonatol. 2002;7(4):293–299
  35. Demmler G. Screening for congenital cytomegalovirus infection: a tapestry of controversies. J Pediatrics. 2005;142(2):162–164
  36. Cannon M, Davis K. Washing our hands of the congenital cytomegalovirus disease epidemic. BMC Public Health. 2005;5(1):70
  37. Harvey J, Dennis C-L. Hygiene interventions for prevention of cytomegalovirus infection among childbearing women: systematic review (JAN review). J Adv Nurs. 2008;63(5):440–450
  38. Taber L, Frank A, Yow M, Bagley A. Acquisition of cytomegaloviral infections in families with young children: a serological study. J Infect Dis. 1985;151(5):948–952
  39. Marshall B, Adler S. The frequency of pregnancy and exposure to cytomegalovirus infections among women with a young child in day care. Am J Obstet Gynecol. 2009;200(2):163
  40. Staras S, Flanders W, Dollard S, Pass R, McGowan J, Cannon M. Influence of sexual activity on cytomegalovirus prevalence in the United States, 1988–1994. Sex Transm Dis. 2008;35(5):472–479
  41. American College of Obstetrics and Gynecologists . Perinatal Viral and Parasitic Infections. ACOG Practice Bulletin 20. Washington, DC: ACOG; 2000;
  42. Knowledge and practices of obstetricians and gynecologists regarding cytomegalovirus infection during pregnancy—United States, 2007. MMWR Morb Mortal Wkly Rep. 2008;57(3):65–68
  43. Jeon J, Victor M, Adler S, Arwady A, Demmler G, Fowler K, et al. Knowledge and awareness of congenital cytomegalovirus among women. Infect Dis Obstet Gynecol. 2006;80(383):1–7
  44. Ross D, Victor M, Sumartojo E, Cannon M. Women's knowledge of congenital cytomegalovirus: results from the 2005 Health Styles survey. J Womens Health (Larchmt). 2008;17(5):849–858
  45. Adler S, Finney J, Manganello A, Best A. Prevention of child-to-mother transmission of cytomegalovirus among pregnant women. J Pediatr. 2004;145(4):485–491
  46. Nigro G, Adler S, La Torre R, Best A. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med. 2005;353(13):1350–1362
  47. Jacquemard F, Yamamoto M, Costa J, Romand S, Jaqz-Agrain E, Dejean A, et al. Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection. BJOG. 2007;114(9):113–1121
  48. www.stopcmv.com
  49. www.cmvsupport.org
  50. www.bcm.edu/pedi/infect/cmv
  51. http://www.congenitalcmv.blogspot.com
  52. www.cmvkids.com
  53. www.cmvfoundation.org
  54. cmv@listserv.edu
  55. www.apps.facebook.com/causes
  56. Saunders L. Anything But a Dog!. Unlimited Publishing LLC.; 2009;www.UnlimitedPublishing.com
  57. www.cdc.gov/cmv
  58. McCormick A, Roback L, Mocarski E. HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA). PLoS Pathog. 2008;4(5):e1000063
  59. Pass R, Zahang C, Evans A. Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med. 2009;360(12):1191–1199
  60. Morello C, Kelly L, Munks M, Hill A, Spector D. DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge. J Virol. 2007;81(14):66–75
  61. Bolovan-Fritts C, Spector S. Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction. Blood. 2008;111(1):175–182
  62. Plotkin S. Rubella eradication. Vaccine. 2001;19(25/26):3311–3319
  63. Ross D, Dollard S, Victor M, Sumartojo E, Cannon M. The epidemiology and prevention of congenital cytomegalovirus infection and disease: activities of the Centers for Disease Control and Prevention Workgroup. J Womens Health (Larchtmt). 2006;15(3):224–229

 ☆ This manuscript represents the Keynote Address at the Second International Congenital Cytomegalovirus Conference 2008 held in Atlanta, GA, USA.

PII: S1386-6532(09)00497-1

doi: 10.1016/j.jcv.2009.10.007

Journal of Clinical Virology
Volume 46 , Pages S1-S5 , December 2009